Antigenic behavior of the S-63 mouse leukemia virus.
نویسندگان
چکیده
STUDIES OF ANTIBODIES in mice injected with 5-63 leukemia virus have been reported.1 This study represe ts an extension of that work ( table 1 ) and a study of the correlation between in vitro and in vivo protection tests (table 2). The S-63 virus was originally isolated by DNA extraction of ascites cells obtained from mice in which this form of leukemia had been maintained by cell passage in our laboratories for several years. Serum obtained from survivors of S-63 virus-injected mice protects newborn miCe that have been injected with this agent. Comparative studies were performed between the protection afforded by convalescent sera and antisera produced in rabbits. In some experiments, in order to avoid mouse tissue antibodies, newborn rabbits were first made immunologically tolerant to normal mouse tissues and were later challenged with extracts of leukemic tissues. Because this virus had apparently been carried in the ascites cells in a latent form, immunologic studies were also undertaken to determine the relation of the virus to the carrier cell.
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عنوان ژورنال:
- Blood
دوره 27 1 شماره
صفحات -
تاریخ انتشار 1966